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Article

PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data.

Bioinformatics (Oxford, England) - 1 Aug 2013

Larson Nicholas B, Fridley Brooke L

Abstract excerpt

SUMMARY: We have developed a novel Bayesian method, PurBayes, to estimate tumor purity and detect intratumor heterogeneity based on next-generation sequencing data of paired tumor-normal tissue samples, which uses finite mixture modeling methods. We demonstrate our approach using simulated data and discuss its performance under varying conditions. AVAILABILITY: PurBayes is implemented as an R package, and source...

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Identifiers

PMID: 23749958
DOI: 10.1093/bioinformatics/btt293
PMCID: PMC3712213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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