Article
Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking.
American journal of physiology. Cell physiology - 15 Nov 2015
Andersen Martin N, Hefting Louise L, Steffensen Annette B, Schmitt Nicole, Olesen Søren-Peter, Olsen Jesper V, Lundby Alicia, Rasmussen Hanne B
Abstract excerpt
The potassium channel Kv7.1 plays critical physiological roles in both heart and epithelial tissues. In heart, Kv7.1 and the accessory subunit KCNE1 forms the slowly activating delayed-rectifier potassium current current, which is enhanced by protein kinase A (PKA)-mediated phosphorylation. The observed current increase requires both phosphorylation of Kv7.1 and the presence of KCNE1. However, PKA also stimulates...
Topics
- Animals
- Cell Line
- Cyclic AMP-Dependent Protein Kinases
- Dogs
- Endosomal Sorting Complexes Required for Transport
- Gene Expression Regulation, Enzymologic
- Gene Knockdown Techniques
- KCNQ1 Potassium Channel
- Mutation
- Nedd4 Ubiquitin Protein Ligases
- Protein Conformation