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Article

Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking.

American journal of physiology. Cell physiology - 15 Nov 2015

Andersen Martin N, Hefting Louise L, Steffensen Annette B, Schmitt Nicole, Olesen Søren-Peter, Olsen Jesper V, Lundby Alicia, Rasmussen Hanne B

Abstract excerpt

The potassium channel Kv7.1 plays critical physiological roles in both heart and epithelial tissues. In heart, Kv7.1 and the accessory subunit KCNE1 forms the slowly activating delayed-rectifier potassium current current, which is enhanced by protein kinase A (PKA)-mediated phosphorylation. The observed current increase requires both phosphorylation of Kv7.1 and the presence of KCNE1. However, PKA also stimulates...

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Identifiers

PMID: 26405101
DOI: 10.1152/ajpcell.00383.2014
PMCID: PMC4652078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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