Article
Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1.
Circulation research - 10 Oct 2008
Snabaitis Andrew K, Cuello Friederike, Avkiran Metin
Abstract excerpt
Sarcolemmal Na(+)/H(+) exchanger (NHE) activity is mediated by NHE isoform 1 (NHE1), which is subject to regulation by protein kinases. Our objectives were to determine whether NHE1 is phosphorylated by protein kinase B (PKB), identify any pertinent phosphorylation site(s), and delineate the functional consequences of such phosphorylation. Active PKBalpha phosphorylated in vitro a glutathione S-transferase...
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