Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation.

doi:10.1042/BJ20070713

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Article

Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation.

The Biochemical journal - 1 Mar 2008

Vergarajauregui Silvia, Oberdick Ross, Kiselyov Kirill, Puertollano Rosa

Abstract excerpt

Mucolipins constitute a family of cation channels with homology with the transient receptor potential family. Mutations in MCOLN1 (mucolipin 1) have been linked to mucolipidosis type IV, a recessive lysosomal storage disease characterized by severe neurological and ophthalmologic abnormalities. At present, little is known about the mechanisms that regulate MCOLN1 activity. In the present paper, we addressed...

Topics

Cell Line
Cyclic AMP-Dependent Protein Kinases
Electrophysiology
Glutathione Transferase
Humans
Kidney
Kinetics
Lysosomes
Mucolipidoses
Mutation
Phosphorylation
Plasmids
Recombinant Proteins
TRPM Cation Channels
Transient Receptor Potential Channels

Source

Open in PubMed

Identifiers

PMID: 17988215
DOI: 10.1042/BJ20070713

Genes

MCOLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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