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Article

Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation.

The Biochemical journal - 1 Mar 2008

Vergarajauregui Silvia, Oberdick Ross, Kiselyov Kirill, Puertollano Rosa

Abstract excerpt

Mucolipins constitute a family of cation channels with homology with the transient receptor potential family. Mutations in MCOLN1 (mucolipin 1) have been linked to mucolipidosis type IV, a recessive lysosomal storage disease characterized by severe neurological and ophthalmologic abnormalities. At present, little is known about the mechanisms that regulate MCOLN1 activity. In the present paper, we addressed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17988215
DOI: 10.1042/BJ20070713

Genes

MCOLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation.PMID 17988215Read ↗

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Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Finely Alleviate Diabetes Mellitus via a Ca <sup>2+</sup> - CaMKKβ-AMPK pathwaySemantic proximity Read ↗

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