Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents.

doi:10.3233/JAD-140519

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Article

Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Dell'Acqua Flavio, Khan Wasim, Gottlieb Natalie, Giampietro Vincent, Ginestet Cedric, Bouls David, Newhouse Steven, Dobson Richard, Banaschewski Tobias, Barker Gareth J, Bokde Arun L W, Büchel Christian, Conrod Patricia, Flor Herta, Frouin Vincent, Garavan Hugh, Gowland Penny, Heinz Anreas, Lemaítre Hervé, Nees Frauke, Paus Tomas, Pausova Zdenka, Rietschel Marcella, Smolka Michael N, Ströhle Andreas, Gallinat Jean, Westman Eric, Schumann Gunther, Lovestone Simon, Simmons Andrew

Abstract excerpt

The apolipoprotein E (APOE) ɛ4 allele is the best established genetic risk factor for Alzheimer's disease (AD) and has been previously associated with alterations in structural gray matter and changes in functional brain activity in healthy middle-aged individuals and older non-demented subjects. In order to determine the neural mechanism by which APOE polymorphisms affect white matter (WM) structure, we...

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PMID: 26401776
DOI: 10.3233/JAD-140519

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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