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Article

JC polyomavirus mutants escape antibody-mediated neutralization.

Science translational medicine - 23 Sept 2015

Ray Upasana, Cinque Paola, Gerevini Simonetta, Longo Valeria, Lazzarin Adriano, Schippling Sven, Martin Roland, Buck Christopher B, Pastrana Diana V

Abstract excerpt

JC polyomavirus (JCV) persistently infects the urinary tract of most adults. Under conditions of immune impairment, JCV causes an opportunistic brain disease, progressive multifocal leukoencephalopathy (PML). JCV strains found in the cerebrospinal fluid of PML patients contain distinctive mutations in surface loops of the major capsid protein, VP1. We hypothesized that VP1 mutations might allow the virus to evade...

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Identifiers

PMID: 26400912
DOI: 10.1126/scitranslmed.aab1720
PMCID: PMC6290683

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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