Article

Antibody Escape by Polyomavirus Capsid Mutation Facilitates Neurovirulence

2020-07-15

Abstract excerpt

<h4>SUMMARY</h4> JCPyV polyomavirus, a member of the human virome, causes Progressive Multifocal Leukoencephalopathy (PML), an oft-fatal demyelinating brain disease in individuals receiving immunomodulatory therapies. Mutations in the major viral capsid protein, VP1, are common in JCPyV from PML patients (JCPyV-PML) but whether they confer neurovirulence or escape from virus-neutralizing antibody (nAb) in vivo i...

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Literature Corpus work: f1745934-e4e2-545f-8b8a-dff14cd87225
DOI: 10.1101/2020.07.14.203281

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