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Article

Structural characterization of human neutralizing antibodies against JC and BK polyomaviruses.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2026

Harprecht Christina, Ströh Luisa J, O'Hara Bethany A, Freytag Jasmin, Nagel Felix, Haley Sheila A, Stierhof York-Dieter, Atwood Walter J, Stehle Thilo

Abstract excerpt

The human JC polyomavirus (JCPyV) causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals. JCPyV frequently undergoes mutations in PML patients, and these variants are thought to establish "antibody recognition holes" that enable the virus to circumvent the antibody response of infected individuals. Many of these PML-associated mutations cluster in...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Capsid Proteins

Share to Crystallography, X-Ray

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Share to Leukoencephalopathy, Progressive Multifocal

Source

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Identifiers

PMID: 42406959
DOI: 10.1073/pnas.2603048123
PMCID: PMC13367825

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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