Article

T Cell Deficiency Precipitates Antibody Evasion and Emergence of Neurovirulent Polyomavirus

2022-02-25

Abstract excerpt

<h4>Summary</h4> JC polyomavirus (JCPyV) causes Progressive Multifocal Leukoencephalopathy (PML), a life-threatening brain disease in T cell immunosuppressed patients. PML patients often carry mutations in the JCPyV VP1 capsid protein. These mutations confer resistance to neutralizing VP1 antibodies (Ab). We found that T cell insufficiency during persistent infection, in the setting of monospecific VP1 Ab, was re...

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Literature Corpus work: 3671ae55-e09b-5cc7-b428-81825874e8e9
DOI: 10.1101/2022.02.25.481945

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