Article
Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1.
mAbs - 1 Jan 2015
Chen Gang, Gorelik Leonid, Simon Kenneth J, Pavlenco Alevtina, Cheung Anne, Brickelmaier Margot, Chen Ling Ling, Jin Ping, Weinreb Paul H, Sidhu Sachdev S
Abstract excerpt
Polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy (PML), a rare and frequently fatal brain disease that afflicts a small fraction of the immune-compromised population, including those affected by AIDS and transplantation recipients on immunosuppressive drug therapy. Currently there is no specific therapy for PML. The major capsid viral protein 1 (VP1) involved in binding...
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