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Article

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence.

eLife - 17 Sept 2020

Lauver Matthew D, Goetschius Daniel J, Netherby-Winslow Colleen S, Ayers Katelyn N, Jin Ge, Haas Daniel G, Frost Elizabeth L, Cho Sung Hyun, Bator Carol M, Bywaters Stephanie M, Christensen Neil D, Hafenstein Susan L, Lukacher Aron E

Abstract excerpt

JCPyV polyomavirus, a member of the human virome, causes progressive multifocal leukoencephalopathy (PML), an oft-fatal demyelinating brain disease in individuals receiving immunomodulatory therapies. Mutations in the major viral capsid protein, VP1, are common in JCPyV from PML patients (JCPyV-PML) but whether they confer neurovirulence or escape from virus-neutralizing antibody (nAb) in vivo is unknown. A mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32940605
DOI: 10.7554/eLife.61056
PMCID: PMC7541085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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