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Article

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses.

Cell reports - 31 Oct 2017

Geoghegan Eileen M, Pastrana Diana V, Schowalter Rachel M, Ray Upasana, Gao Wei, Ho Mitchell, Pauly Gary T, Sigano Dina M, Kaynor Campbell, Cahir-McFarland Ellen, Combaluzier Benoit, Grimm Jan, Buck Christopher B

Abstract excerpt

Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of sialylated glycans, which are thought to serve as receptors for the infectious entry of wild-type JCV. In this report, we show that non-sialylated glycosaminoglycans (GAGs) can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29091757
DOI: 10.1016/j.celrep.2017.10.027
PMCID: PMC5687836

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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