Article
Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs.
Scientific reports - 24 Sept 2015
Qian Lili, Tang Maoxue, Yang Jinzeng, Wang Qingqing, Cai Chunbo, Jiang Shengwang, Li Hegang, Jiang Ke, Gao Pengfei, Ma Dezun, Chen Yaoxing, An Xiaorong, Li Kui, Cui Wentao
Abstract excerpt
Myostatin (MSTN) is a dominant inhibitor of skeletal muscle development and growth. Mutations in MSTN gene can lead to muscle hypertrophy or double-muscled (DM) phenotype in cattle, sheep, dog and human. However, there has not been reported significant muscle phenotypes in pigs in association with MSTN mutations. Pigs are an important source of meat production, as well as serve as a preferred animal model for the...
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