Article
Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin.
Cancer research - 15 Aug 1999
Romagnolo B, Berrebi D, Saadi-Keddoucci S, Porteu A, Pichard A L, Peuchmaur M, Vandewalle A, Kahn A, Perret C
Abstract excerpt
Mutations in the adenomatous polyposis coli gene or activating mutations in the beta-catenin gene itself are thought to be responsible for the excessive beta-catenin signaling involved in intestinal carcinogenesis. We generated transgenic mice that expressed large amounts of a NH2-terminally truncated mutant beta-catenin (deltaN131beta-catenin) in the intestine. These mice had multifocal dysplastic lesions in the...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Animals
- Cadherins
- Cytoskeletal Proteins
- Gene Expression Regulation, Neoplastic
- Intestinal Diseases
- Intestinal Neoplasms
- Mice
- Mice, Transgenic