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Article

Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin.

Cancer research - 15 Aug 1999

Romagnolo B, Berrebi D, Saadi-Keddoucci S, Porteu A, Pichard A L, Peuchmaur M, Vandewalle A, Kahn A, Perret C

Abstract excerpt

Mutations in the adenomatous polyposis coli gene or activating mutations in the beta-catenin gene itself are thought to be responsible for the excessive beta-catenin signaling involved in intestinal carcinogenesis. We generated transgenic mice that expressed large amounts of a NH2-terminally truncated mutant beta-catenin (deltaN131beta-catenin) in the intestine. These mice had multifocal dysplastic lesions in the...

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PMID: 10463573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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