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Article

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

Gastroenterology - 1 Jun 2009

Pollard Patrick, Deheragoda Maesha, Segditsas Stefania, Lewis Annabelle, Rowan Andrew, Howarth Kimberley, Willis Lisa, Nye Emma, McCart Amy, Mandir Nikki, Silver Andrew, Goodlad Robert, Stamp Gordon, Cockman Matthew, East Philip, Spencer-Dene Bradley, Poulsom Richard, Wright Nicholas, Tomlinson Ian

Abstract excerpt

BACKGROUND & AIMS: We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/degradation repeats (20AARs); very few intestinal tumors have proteins with no 20AARs. The...

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Share to Adenomatous Polyposis Coli
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Source

Identifiers

PMID: 19248780
DOI: 10.1053/j.gastro.2009.02.058

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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