Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring.

doi:10.1111/dmcn.12929

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Article

Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring.

Developmental medicine and child neurology - 1 Jun 2016

Prasoona Kattekola R, Sunitha Tella, Srinadh Buragadda, Deepika Madireddy L N, Kumari Tiruvatturu M, Jyothy Akka

Abstract excerpt

AIM: This study aimed to evaluate the role of methylenetetrahydrofolate dehydrogenase (MTHFD1) G1958A variant (rs2236225) as a 'maternal, paternal, or embryonic' genetic risk factor for neural tube defect (NTD) susceptibility. It also estimated differential associations based on type of NTD, offspring sex, maternal-paternal-offspring genotype incompatibility, and parent-of-origin effects (POE) using both...

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PMID: 26394717
DOI: 10.1111/dmcn.12929

Genes

MTHFD1

Variants

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