Article
Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers.
Asia Pacific journal of clinical nutrition - 1 Jan 2000
Nauman Nuzhat, Jalali Samina, Shami Sajjad, Rafiq Shireen, Große Greta, Hilger Alina C, Zhang Rhong, Mansoor Saira, Ludwig Michael, Reutter Heiko
Abstract excerpt
BACKGROUND AND OBJECTIVES: There is considerable evidence that periconceptional maternal folate deficiency and coding variants in maternal genes coding for critical enzymes in the folate pathway are associated with neural tube defects (NTDs) in offspring. In a case-control study we investigated C677T polymorphism in the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene in case and control mothers of...
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