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Article

Maternal association and influence of DHFR 19 bp deletion variant predisposes foetus to anencephaly susceptibility: a family-based triad study.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Nov 2018

Prasoona K R, Sunitha T, Srinadh B, Muni Kumari T, Jyothy A

Abstract excerpt

OBJECTIVE: Previous studies have not used family-based methods to evaluate maternal-paternal genetic effects of the folate metabolizing enzyme, dihydro folate reductase (DHFR) essential during embryogenesis. Present study focuses on evaluating the association and influence of parental genetic effects of DHFR 19 bp deletion in the development of foetal neural tube defects (NTDs) using family-based triad approach....

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Identifiers

PMID: 29708443
DOI: 10.1080/1354750X.2018.1471619

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DHFR

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