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Article

Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India.

Birth defects research - 15 Aug 2018

Paul Silpita, Sadhukhan Susanta, Munian Dinesh, Bankura Biswabandhu, Das Madhusudan

Abstract excerpt

BACKGROUND: Worldwide, Neural tube defects (NTDs) are considered as major clinical problems imposing a huge socio-economic burden for both affected individuals and their families. In India, the prevalence of Neural tube defects is significantly high. This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase...

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Source

Identifiers

PMID: 30120883
DOI: 10.1002/bdr2.1365

Genes

DHFR
FOLH1
MTHFR

Variants

rs1801133
rs202676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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