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Article

Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches.

Birth defects research - 17 Jul 2017

K Rebekah Prasoona, Tella Sunitha, Buragadda Srinadh, Tiruvatturu Muni Kumari, Akka Jyothy

Abstract excerpt

BACKGROUND: Neural tube defects (NTDs) are caused by the failure of neural tube formation which occurs during early embryonic development. NTDs are the most severe and leading cause of fetal mortality. Serine hydroxymethyl transferase (SHMT1) provides one-carbon units necessary for embryogenesis and defects in one-carbon production result in specific pathological conditions during pregnancy. The present study is...

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Source

Identifiers

PMID: 28762673
DOI: 10.1002/bdr2.23623

Genes

SHMT1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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