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Article

LRP2 gene variants and their haplotypes strongly influence the risk of developing neural tube defects in the fetus: a family-triad study from South India.

Metabolic brain disease - 1 Aug 2018

K Rebekah Prasoona, T Sunitha, B Srinadh, T Muni Kumari, A Jyothy

Abstract excerpt

Neural tube defects (NTDs) are the leading cause of infant deaths worldwide. Lipoprotein related receptor 2 (LRP2) has been shown to play a crucial role in neural tube development in mouse models. However, the role of LRP2 gene in the development of human NTDs is not yet known. In view of this, family-based triad approach has been followed considering 924 subjects comprising 124 NTD case-parent trios and 184...

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Identifiers

PMID: 29728895
DOI: 10.1007/s11011-018-0242-2

Genes

LRP2

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