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Article

The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility.

Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2015

Linser Rasmus, Salvi Nicola, Briones Rodolfo, Rovó Petra, de Groot Bert L, Wagner Gerhard

Abstract excerpt

Regulated intramembrane proteolysis (RIP) is a conserved mechanism crucial for numerous cellular processes, including signaling, transcriptional regulation, axon guidance, cell adhesion, cellular stress responses, and transmembrane protein fragment degradation. Importantly, it is relevant in various diseases including Alzheimer's disease, cardiovascular diseases, and cancers. Even though a number of structures of...

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Source

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Identifiers

PMID: 26392539
DOI: 10.1073/pnas.1513782112
PMCID: PMC4603520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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