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Article

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor.

Molecular cell - 18 Feb 2016

Fu Qingshan, Fu Tian-Min, Cruz Anthony C, Sengupta Prabuddha, Thomas Stacy K, Wang Shuqing, Siegel Richard M, Wu Hao, Chou James J

Abstract excerpt

Fas (CD95, Apo-1, or TNFRSF6) is a prototypical apoptosis-inducing death receptor in the tumor necrosis factor receptor (TNFR) superfamily. While the extracellular domains of TNFRs form trimeric complexes with their ligands and the intracellular domains engage in higher-order oligomerization, the role of the transmembrane (TM) domains is unknown. We determined the NMR structures of mouse and human Fas TM domains...

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Identifiers

PMID: 26853147
DOI: 10.1016/j.molcel.2016.01.009
PMCID: PMC4761300

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