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Article

Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

Cell - 1 Sept 2000

Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich H D, Jentsch S

Abstract excerpt

Processing of integral membrane proteins in order to liberate active proteins is of exquisite cellular importance. Examples are the processing events that govern sterol regulation, Notch signaling, the unfolded protein response, and APP fragmentation linked to Alzheimer's disease. In these cases, the proteins are thought to be processed by regulated intramembrane proteolysis, involving site-specific,...

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Source

Identifiers

PMID: 11007476
DOI: 10.1016/s0092-8674(00)00080-5

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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