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Article

Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP

6 Dec 2017

Abstract excerpt

C/EBP-homologous protein (CHOP) is a key determinant of the apoptotic response to endoplasmic reticulum stress or DNA damage. As a member of the C/EBP family, CHOP contains a low complexity N-terminal region involved in transcriptional activation, followed by a bZIP that binds DNA after dimerization. However, in contrast to other C/EBPs, CHOP directs binding to non-canonical C/EBP sites due to unique...

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PMID: 29211802
DOI: 10.1371/journal.pone.0189171

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