Article

Substrate specificity in a designed RAS-targeting protease is coupled to active site and distal motions

2026-01-15

Abstract excerpt

<h4>Design: </h4> ing proteases with tailored substrate specificity has emerged as a powerful strategy for manipulating protein function in cells. RAS, a key regulator of cell survival and proliferation, is a compelling target for such approaches. Mutations in RAS are involved in about one-third of all human cancers and drive the hyperactive signaling that promotes tumorigenesis, growth, and metastasis in cancers...

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Literature Corpus work: 3dbcd97a-24dc-573a-b85e-395626e8ca05
DOI: 10.64898/2026.01.15.699477

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