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Article

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective.

Current neuropharmacology - 1 Jan 2016

Dalton James A R, Lans Isaias, Rovira Xavier, Malhaire Fanny, Gómez-Santacana Xavier, Pittolo Silvia, Gorostiza Pau, Llebaria Amadeu, Goudet Cyril, Pin Jean-Philippe, Giraldo Jesús

Abstract excerpt

Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a particularly high-profile target because its positive or negative allosteric modulation can potentially treat schizophrenia or anxiety and chronic pain, respectively. Here, we computationally and experimentally probe the functional binding of a novel...

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Identifiers

PMID: 26391742
DOI: 10.2174/1570159x13666150407231417
PMCID: PMC4983757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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