Article

Optical Control of the Cardiac Rhythm with Photoswitchable NaV1.5 Channel Blockers

2025-05-28

Abstract excerpt

<title>Abstract</title> <p> Voltage-gated sodium channel Na <sub>V</sub> 1.5 is essential for cardiac excitability, mediating the rapid depolarization phase of the cardiac action potential (AP) and ensuring proper electrical conduction in the heart. Dysfunction of Na <sub>V</sub> 1.5 is implicated in life-threatening arrhythmias, making it a critical therapeutic target. Acting as a Na <sub>V</sub> 1.5 open...

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Literature Corpus work: 18f28da6-4817-58f2-836a-11c53cd8c05b
DOI: 10.21203/rs.3.rs-6532136/v1

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