Article
Atomistic design of microbial opsin-based blue-shifted optogenetics tools.
Nature communications - 15 May 2015
Kato Hideaki E, Kamiya Motoshi, Sugo Seiya, Ito Jumpei, Taniguchi Reiya, Orito Ayaka, Hirata Kunio, Inutsuka Ayumu, Yamanaka Akihiro, Maturana Andrés D, Ishitani Ryuichiro, Sudo Yuki, Hayashi Shigehiko, Nureki Osamu
Abstract excerpt
Microbial opsins with a bound chromophore function as photosensitive ion transporters and have been employed in optogenetics for the optical control of neuronal activity. Molecular engineering has been utilized to create colour variants for the functional augmentation of optogenetics tools, but was limited by the complexity of the protein-chromophore interactions. Here we report the development of blue-shifted...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.