Article
Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity.
Immunity - 20 Oct 2015
Zlotnikov-Klionsky Yael, Nathansohn-Levi Bar, Shezen Elias, Rosen Chava, Kagan Sivan, Bar-On Liat, Jung Steffen, Shifrut Eric, Reich-Zeliger Shlomit, Friedman Nir, Aharoni Rina, Arnon Ruth, Yifa Oren, Aronovich Anna, Reisner Yair
Abstract excerpt
Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic...
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