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Article

Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice.

Frontiers in immunology - 1 Jan 2020

Majdoubi Abdelilah, Lee Jun Seong, Kishta Osama A, Balood Mohammad, Moulefera Mohamed Abdelwafi, Ishido Satoshi, Talbot Sébastien, Cheong Cheolho, Alquier Thierry, Thibodeau Jacques

Abstract excerpt

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. However, the mechanisms that trigger the underlying adipose tissues inflammation are not completely understood. Here, we show that the E3 ubiquitin ligase March1 controls the phenotypic and functional properties of CD8+ T cells in mice white adipose tissue. In a diet-induced obesity model, mice lacking March1 [March1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32973799
DOI: 10.3389/fimmu.2020.01953
PMCID: PMC7461985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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