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Article

Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.

Molecular and cellular endocrinology - 5 Apr 2020

Porsche Cara E, Delproposto Jennifer B, Patrick Elise, Zamarron Brian F, Lumeng Carey N

Abstract excerpt

Adipose tissue derived chronic inflammation is a critical component of obesity induced type II diabetes. Major histocompatibility complex II (MHCII) mediated T cell activation within adipose tissue is one mechanism that contributes to this phenotype. However, the contribution of dendritic cells as professional antigen presenting cells in adipose issue has not previously been explored. Using ItgaxCre x MHCIIfl/fl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31987897
DOI: 10.1016/j.mce.2020.110740
PMCID: PMC7197735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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