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Article

Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [18F]FEPPA.

The American journal of psychiatry - 1 Feb 2017

Hafizi Sina, Tseng Huai-Hsuan, Rao Naren, Selvanathan Thiviya, Kenk Miran, Bazinet Richard P, Suridjan Ivonne, Wilson Alan A, Meyer Jeffrey H, Remington Gary, Houle Sylvain, Rusjan Pablo M, Mizrahi Romina

Abstract excerpt

OBJECTIVE: Neuroinflammation and abnormal immune responses are increasingly implicated in the pathophysiology of schizophrenia. Previous positron emission tomography (PET) studies targeting the translocator protein 18 kDa (TSPO) have been limited by high nonspecific binding of the first-generation radioligand, low-resolution scanners, small sample sizes, and psychotic patients being on antipsychotics or not being...

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Source

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Identifiers

PMID: 27609240
DOI: 10.1176/appi.ajp.2016.16020171
PMCID: PMC5342628

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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