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Article

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study.

Journal of human genetics - 1 Dec 2015

Li Jin, Lange Leslie A, Sabourin Jeremy, Duan Qing, Valdar William, Willis Monte S, Li Yun, Wilson James G, Lange Ethan M

Abstract excerpt

Lipoprotein (a) (Lp(a)) is an independent risk factor for cardiovascular disease. Lp(a) levels in African Americans (AAs) are much higher compared with that in European Americans. We conducted a genome- and an exome-wide association study of Lp(a) among 2895 AAs participating in the Jackson Heart Study. We observed that local ancestry at 6q25.3 was an important risk factor for Lp(a) in AAs, and that multiple...

Topics

Black or African American
Apolipoproteins E
Cardiovascular Diseases
Chromosomes, Human, Pair 6
Female
Genome-Wide Association Study
Humans
Lipoprotein(a)
Male
Mississippi
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

White People

Source

Identifiers

PMID: 26377243
DOI: 10.1038/jhg.2015.107

Genes

LPA
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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