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Article

Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

PloS one - 24 Jan 2011

Deo Rahul C, Wilson James G, Xing Chao, Lawson Kim, Kao W H Linda, Reich David, Tandon Arti, Akylbekova Ermeg, Patterson Nick, Mosley Thomas H, Boerwinkle Eric, Taylor Herman A

Abstract excerpt

Lipoprotein(a) (Lp(a)) is an important causal cardiovascular risk factor, with serum Lp(a) levels predicting atherosclerotic heart disease and genetic determinants of Lp(a) levels showing association with myocardial infarction. Lp(a) levels vary widely between populations, with African-derived populations having nearly 2-fold higher Lp(a) levels than European Americans. We investigated the genetic basis of this...

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Source

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Identifiers

PMID: 21283670
DOI: 10.1371/journal.pone.0014581
PMCID: PMC3025914

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.PMID 21283670Read ↗

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Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.Semantic proximity Read ↗

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