Article
Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.
Journal of medical genetics - 1 Dec 2006
Chretien J-P, Coresh J, Berthier-Schaad Y, Kao W H L, Fink N E, Klag M J, Marcovina S M, Giaculli F, Smith M W
Abstract excerpt
BACKGROUND: The extent which universally common or population-specific alleles can explain between-population variations in phenotypes is unknown. The heritable coronary heart disease risk factor lipoprotein(a) (Lp(a)) level provides a useful case study of between-population variation, as the aet...
Topics
- Adolescent
- Adult
- Black or African American
- Aged
- Aged, 80 and over
- Alleles
- Cohort Studies
- Gene Frequency
- Humans
- Kidney Failure, Chronic
- Linkage Disequilibrium
- Lipoprotein(a)
- Middle Aged
- Polymorphism, Single Nucleotide