Article
Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.
Journal of medical genetics - 1 Dec 2006
Chretien J-P, Coresh J, Berthier-Schaad Y, Kao W H L, Fink N E, Klag M J, Marcovina S M, Giaculli F, Smith M W
Abstract excerpt
BACKGROUND: The extent which universally common or population-specific alleles can explain between-population variations in phenotypes is unknown. The heritable coronary heart disease risk factor lipoprotein(a) (Lp(a)) level provides a useful case study of between-population variation, as the aetiology of twofold higher Lp(a) levels in African populations compared with non-African populations is unknown....
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