Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

doi:10.1038/s41467-018-04668-w

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Article

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

Nature communications - 4 Jul 2018

Zekavat Seyedeh M, Ruotsalainen Sanni, Handsaker Robert E, Alver Maris, Bloom Jonathan, Poterba Timothy, Seed Cotton, Ernst Jason, Chaffin Mark, Engreitz Jesse, Peloso Gina M, Manichaikul Ani, Yang Chaojie, Ryan Kathleen A, Fu Mao, Johnson W Craig, Tsai Michael, Budoff Matthew, Vasan Ramachandran S, Cupples L Adrienne, Rotter Jerome I, Rich Stephen S, Post Wendy, Mitchell Braxton D, Correa Adolfo, Metspalu Andres, Wilson James G, Salomaa Veikko, Kellis Manolis, Daly Mark J, Neale Benjamin M, McCarroll Steven, Surakka Ida, Esko Tonu, Ganna Andrea, Ripatti Samuli, Kathiresan Sekar, Natarajan Pradeep

Abstract excerpt

Lipoprotein(a), Lp(a), is a modified low-density lipoprotein particle that contains apolipoprotein(a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we use deep-coverage whole genome sequencing in 8392 individuals of European and African ancestry to discover and interpret both single-nucleotide variants and copy...

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Identifiers

PMID: 29973585
DOI: 10.1038/s41467-018-04668-w
PMCID: PMC6031652

Genes

LPA
SORT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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