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Article

Pervasiveness of HLA allele-specific expression loss across tumor types.

Genome medicine - 9 Feb 2023

Filip Ioan, Wang Anqi, Kravets Oleksandr, Orenbuch Rose, Zhao Junfei, Perea-Chamblee Tomin E, Manji Gulam A, López de Maturana Evangelina, Malats Núria, Olive Kenneth P, Rabadan Raul

Abstract excerpt

BACKGROUND: Efficient presentation of mutant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune-mediated killing of cancer cells. According to recent reports, patient HLA-I genotypes can impact the efficacy of cancer immunotherapy, and the somatic loss of HLA-I heterozygosity has been established as a factor in immune evasion. While global deregulated expression of...

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Identifiers

PMID: 36759885
DOI: 10.1186/s13073-023-01154-x
PMCID: PMC9912643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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