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Article

No Association of IFNL4 Genotype With Opportunistic Infections and Cancers Among Men With Human Immunodeficiency Virus 1 Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 8 Feb 2023

Fang Michelle Z, Jackson Sarah S, Pfeiffer Ruth M, Kim Eun-Young, Chen Sabrina, Hussain Shehnaz K, Jacobson Lisa P, Martinson Jeremy, Prokunina-Olsson Ludmila, Thio Chloe L, Duggal Priya, Wolinsky Steven, O'Brien Thomas R

Abstract excerpt

BACKGROUND: IFNL4 genetic variants that are strongly associated with clearance of hepatitis C virus have been linked to risk of certain opportunistic infections (OIs) and cancers, including Kaposi sarcoma, cytomegalovirus infection, and herpes simplex virus infection. As the interferon (IFN) λ family plays a role in response to viral, bacterial, and fungal infections, IFNL4 genotype might affect risk for a wide...

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PMID: 36573283
DOI: 10.1093/cid/ciac447
PMCID: PMC10169417

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