Article
Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C.
AIDS (London, England) - 13 Nov 2013
Krämer Benjamin, Nischalke Hans Dieter, Boesecke Christoph, Ingiliz Patrick, Voigt Esther, Mauss Stefan, Stellbrink Hans-Jürgen, Baumgarten Axel, Rockstroh Juergen K, Spengler Ulrich, Nattermann Jacob
Abstract excerpt
The IFNL4 ss469415590 polymorphism has recently be shown to better predict treatment response in chronic hepatitis than the IL28B rs12979860 variant. However, no data exist in patients with HIV/hepatitis C virus (HCV) coinfection. Analysing 206 HCV(+)/HIV(+) and 162 HCV(+)/HIV(-) patients, we found that compared with IL28B rs12979860, IFNL4 ss469415590 was strongly associated with response to interferon/ribavirin...
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