Article
The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Nov 2021
Møhlenberg Michelle, Monrad Ida, Vibholm Line K, Nielsen Stine S F, Frattari Giacomo Schmidt, Schleimann Mariane Høgsbjerg, Olesen Rikke, Kjolby Mads, Gunst Jesper Damsgaard, Søgaard Ole Schmeltz, O'Brien Thomas R, Tolstrup Martin, Hartmann Rune
Abstract excerpt
Genetic polymorphisms at the IFNL4 loci are known to influence the clinical outcome of several different infectious diseases. Best described is the association between the IFNL4 genotype and hepatitis C virus clearance. However, an influence of the IFNL4 genotype on the adaptive immune system was suggested by several studies but never investigated in humans. In this cross-sectional study, we have genotyped 201...
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