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Article

Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection.

AIDS research and therapy - 15 Apr 2020

Freitas Inês T, Tinago Willard, Sawa Hirofumi, McAndrews Julie, Doak Brenda, Prior-Fuller Charlotte, Sheehan Gerard, Lambert John S, Muldoon Eavan, Cotter Aoife G, Hall William W, Mallon Patrick W G, Carr Michael J

Abstract excerpt

BACKGROUND: The objectives of this study were to investigate the relationships between polymorphisms at the interferon lambda (IFNL) locus and CD4+:CD8+ ratio normalisation in people living with HIV (PLWH) on effective antiretroviral therapy (ART); and to examine whether these polymorphisms influence the composition of T lymphocyte compartments in long-term treated HIV-1 infection. METHODS: A cross-sectional...

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Identifiers

PMID: 32295609
DOI: 10.1186/s12981-020-00269-0
PMCID: PMC7194102

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