Article

ABCC1/MRP1 exports cGAMP and modulates cGAS-dependent immunity

2021-12-03

Abstract excerpt

The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that activates the antiviral response through the adapter protein Stimulator of Interferon Genes (STING). cGAMP is negatively charged and cannot passively cross cell membranes, but recent advances have established a role for extracellular cGAMP as...

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Identifiers and source

Literature Corpus work: 4530ce9e-2561-50a8-b2e6-7e34dd979ec9
DOI: 10.1101/2021.12.03.470980

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