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Article

ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13.

The Journal of cell biology - 14 Sept 2015

Lang Alexander B, John Peter Arun T, Walter Peter, Kornmann Benoît

Abstract excerpt

The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex tethers the endoplasmic reticulum and the mitochondria. It is thought to facilitate interorganelle lipid exchange and influence mitochondrial dynamics and mitochondrial DNA maintenance. Despite this important role, ERMES is not found in metazoans. Here, we identified single amino acid substitutions in Vps13 (vacuolar protein sorting 13), a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26370498
DOI: 10.1083/jcb.201502105
PMCID: PMC4576869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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