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Article

Genetic Dissection of Vps13 Regulation in Yeast Using Disease Mutations from Human Orthologs.

International journal of molecular sciences - 8 Jun 2021

Park Jae-Sook, Hollingsworth Nancy M, Neiman Aaron M

Abstract excerpt

The VPS13 family of proteins have emerged as key players in intracellular lipid transport and human health. Humans have four different VPS13 orthologs, the dysfunction of which leads to different diseases. Yeast has a single VPS13 gene, which encodes a protein that localizes to multiple different membrane contact sites. The yeast vps13Δ mutant is pleiotropic, exhibiting defects in sporulation, protein...

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Identifiers

PMID: 34201352
DOI: 10.3390/ijms22126200
PMCID: PMC8229349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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