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Article

ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis.

The Journal of cell biology - 7 Dec 2020

English Alyssa M, Schuler Max-Hinderk, Xiao Tianyao, Kornmann Benoît, Shaw Janet M, Hughes Adam L

Abstract excerpt

Mitochondria are dynamic organelles with essential roles in signaling and metabolism. We recently identified a cellular structure called the mitochondrial-derived compartment (MDC) that is generated from mitochondria in response to amino acid overabundance stress. How cells form MDCs is unclear. Here, we show that MDCs are dynamic structures that form and stably persist at sites of contact between the ER and...

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Identifiers

PMID: 33090183
DOI: 10.1083/jcb.202002144
PMCID: PMC7588143

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