Article

VPS13D bridges the ER to Miro containing membranes

2020-10-07

Abstract excerpt

Mitochondria, which are excluded from the secretory pathway, depend on lipid transport proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the outer mitochondrial membrane GTPase Gem1 is an accessory factor of ERMES, an ER-mitochondria tethering complex that contains lipid transport domains and that functions, partially redundantly with Vps13, in lipid transfer between the two...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2fb22aca-e37e-52b6-8681-7c06e6424068
DOI: 10.1101/2020.10.07.328906

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VPS13D bridges the ER to Miro containing membranesDOI 10.1101/2020.10.07.328906Read

Proteomic profiling of mitochondrial-derived vesicles in brain reveals enrichment of respiratory complex sub-assemblies and small TIM chaperonesSemantic proximity Read

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repairSemantic proximity Read

Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and diseaseSemantic proximity Read

Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport.Semantic proximity Read

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repairSemantic proximity Read

Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathwaySemantic proximity Read

In-depth study of MPV17: a molecular travel unveiling a mitochondrial calcium regulation functionSemantic proximity Read

ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13.Semantic proximity Read

VPS13A and VPS13C influence lipid droplet abundanceSemantic proximity Read

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13CSemantic proximity Read

The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites.Semantic proximity Read

ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasisSemantic proximity Read