Article

Protein Quantitative Trait Loci Identify Genetically Regulated Immune Proteins Associated with Tuberculosis Progression in People with HIV

2026-03-30

Abstract excerpt

<h4>ABSTRACT</h4> Host genetics alone poorly predicts tuberculosis (TB) progression, particularly in people with HIV (PWH). We performed exploratory cis-protein quantitative trait locus (pQTL) mapping in pre-diagnostic plasma from 60 PWH who later developed active TB and 194 matched non-progressing controls in the Swiss HIV Cohort Study. Stratified analyses identified 26 pQTLs linked to 12 proteins among progress...

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Literature Corpus work: b2b7dde9-b034-54a9-b1bd-60e637b7e2fe
DOI: 10.64898/2026.03.27.26349487

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