Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.

doi:10.1016/j.ajhg.2009.12.008

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Article

Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.

American journal of human genetics - 1 Jan 2010

Ferreira Manuel A R, Mangino Massimo, Brumme Chanson J, Zhao Zhen Zhen, Medland Sarah E, Wright Margaret J, Nyholt Dale R, Gordon Scott, Campbell Megan, McEvoy Brian P, Henders Anjali, Evans David M, Lanchbury Jerry S, Pereyra Florencia, Walker Bruce D, Haas David W, Soranzo Nicole, Spector Tim D, de Bakker Paul I W, Frazer Ian H, Montgomery Grant W, Martin Nicholas G

Abstract excerpt

Abnormal expansion or depletion of particular lymphocyte subsets is associated with clinical manifestations such as HIV progression to AIDS and autoimmune disease. We sought to identify genetic predictors of lymphocyte levels and reasoned that these may play a role in immune-related diseases. We tested 2.3 million variants for association with five lymphocyte subsets, measured in 2538 individuals from the general...

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Identifiers

PMID: 20045101
DOI: 10.1016/j.ajhg.2009.12.008
PMCID: PMC2801744

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