Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Minireview: Were the IGF Signaling Inhibitors All Bad?

14 Sept 2015

Abstract excerpt

Preclinical studies in the 1980s defined a role for IGF signaling in the development and sustainability of the malignant process. Subsequently, antibody, tyrosine kinase, and ligand inhibitors of the IGF receptor were manufactured. In the past decade, numerous clinical trials have tested the efficacy of IGF receptor inhibitors in the treatment of advanced tumors. Early-phase trials in heavily pretreated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Growth Hormone and Insulin-like Growth Factors
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26366975
DOI: 10.1210/me.2015-1157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Minireview: Were the IGF Signaling Inhibitors All Bad?PMID 26366975Read ↗

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapySemantic proximity Read ↗

The decline and fall of the IGF‐I receptorSemantic proximity Read ↗

Drugging IGF-1R in cancer: New insights and emerging opportunitiesSemantic proximity Read ↗

Targeting the IGF-1R: The Tale of the Tortoise and the HareSemantic proximity Read ↗

Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression ProfilingSemantic proximity Read ↗

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancerSemantic proximity Read ↗

The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical ApplicationsSemantic proximity Read ↗

The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent InsightsSemantic proximity Read ↗

Targeting the IGF1 axis in cancer proliferationSemantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.